A Review on Anti-Tumor Mechanisms of Coumarins

doi:10.3389/fonc.2020.592853

Paper

A Review on Anti-Tumor Mechanisms of Coumarins

Published Dec 4, 2020 · DOI · Yi Wu, Jing Xu, Yiting Liu

Frontiers in Oncology

117

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2

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Abstract

Coumarins are a class of compound with benzopyrone as their basic structure. Due to abundant sources, easy synthesis, and various pharmacological activities, coumarins have attracted extensive attention from researchers. In particular, coumarins have very significant anti-tumor abilities and a variety of anti-tumor mechanisms, including inhibition of carbonic anhydrase, targeting PI3K/Akt/mTOR signaling pathways, inducing cell apoptosis protein activation, inhibition of tumor multidrug resistance, inhibition of microtubule polymerization, regulating the reactive oxygen species, and inhibition of tumor angiogenesis, etc. This review focuses on the mechanisms and the research progress of coumarins against cancers in recent years.

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Study Snapshot

Coumarins show significant anti-tumor abilities and diverse mechanisms, including inhibition of carbonic anhydrase, targeting PI3K/Akt/mTOR signaling pathways, inducing cell apoptosis, and inhibiting tumor multidrug resistance.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

A Review on Anti-Tumor Mechanisms of Coumarins

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