Paper
Review article: rabeprazole’s tolerability profile in clinical trials
Published Oct 1, 1999 · Thjodleifsson, Cockburn
Alimentary Pharmacology & Therapeutics
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Abstract
Rabeprazole is a new member of a class of substituted benzimidazole drugs known as proton pump inhibitors. Comparative trials have demonstrated that it is at least as effective as omeprazole for the treatment of gastro‐oesophageal reflux disease (GERD), duodenal ulcers, or gastric ulcers. It is significantly more effective than histamine2‐receptor antagonists for acid suppression, GERD healing and pain relief, and duodenal ulcer healing and pain relief. Adverse events reported during clinical trials provide an important indication of a medication’s tolerability. We demonstrate that rabeprazole has a favourable adverse events profile. It is well tolerated in placebo‐controlled studies and comparative trials with omeprazole and H2‐receptor antagonists. Moreover, no dose adjustments are required for special populations, such as the elderly or patients with renal or mild‐to‐moderate hepatic disease. Adverse events data from clinical trials support the use of rabeprazole as a treatment for acid‐related diseases.
Rabeprazole is an effective and well-tolerated proton pump inhibitor for treating acid-related diseases, with a favorable adverse events profile and no dose adjustments needed for special populations.
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