A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

doi:10.1111/bcpt.13710

Paper

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Published Jan 26, 2022 · Jiangling Peng, Mingjie Fan, Chelsea An

Basic & Clinical Pharmacology & Toxicology

162

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8

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Abstract

Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis extracts which has high affinity on a series of receptors, including Type 1 cannabinoid receptor (CB1), Type 2 cannabinoid receptor (CB2), GPR55, transient receptor potential vanilloid (TRPV) and peroxisome proliferator‐activated receptor gamma (PPARγ). By modulating the activities of these receptors, CBD exhibits multiple therapeutic effects, including neuroprotective, antiepileptic, anxiolytic, antipsychotic, anti‐inflammatory, analgesic and anticancer properties. CBD could also be applied to treat or prevent COVID‐19 and its complications. Here, we provide a narrative review of CBD's applications in human diseases: from mechanism of action to clinical trials.

Literature ReviewHighly Cited

Study Snapshot

CBD exhibits multiple therapeutic effects, including neuroprotective, antiepileptic, anxiolytic, antipsychotic, anti-inflammatory, analgesic, and anticancer properties, and may help treat or prevent COVID-19 and its complications.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

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