Rhein protects against acetaminophen-induced hepatic and renal toxicity.

doi:10.1016/j.fct.2011.04.011

Paper

Rhein protects against acetaminophen-induced hepatic and renal toxicity.

Published Aug 1, 2011 · Yan-Ling Zhao, Guangde Zhou, Hong-bo Yang

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Q1 SJR score

82

Citations

3

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Rhein protects against acetaminophen-induced liver and kidney damage in rats by reducing oxidative stress and restoring liver and kidney function.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Rhein protects against acetaminophen-induced hepatic and renal toxicity.

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References

Citations

Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2/NF-κB/NLRP3/GSDMD signaling pathways.

Diacetylrhein (DAR) has a dose-dependent renoprotective effect on diclofenac-induced acute kidney injury in rats, promoting kidney health by modulating Nrf2/HO-1, TLR4, and NLRP3/GSDMD signaling pathways.

Identification and validation of potential diagnostic signature and immune cell infiltration for NAFLD based on cuproptosis-related genes by bioinformatics analysis and machine learning

This study identified three key cuproptosis-related genes (NFE2L2, DLD, and POLD1) as potential diagnostic markers and immune cell infiltration markers for nonalcoholic fatty liver disease (NAFLD), providing potential targets for treatment and new insights into the disease mechanism.

Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products

Natural products like polyphenols, terpenes, anthraquinones, and sulforaphane can counteract acetaminophen-induced liver injury by activating the hepatocyte antioxidant defense system and reducing oxidative stress damage.

Nephroprotective and nephrotoxic effects of Rhubarb and their molecular mechanisms.

Rhubarb has a nephroprotective effect against chronic kidney disease, but long-term inappropriate use may cause nephrotoxicity.

Renoprotective Effect of Taxifolin in Paracetamol-Induced Nephrotoxicity: Emerging Evidence from an Animal Model

Taxifolin shows promising renoprotective effects in preventing paracetamol-induced nephrotoxicity in rats, mainly through antioxidant activity.

Notoginsenoside Fc ameliorates renal tubular injury and mitochondrial damage in acetaminophen-induced acute kidney injury partly by regulating SIRT3/SOD2 pathway

Notoginsenoside Fc reduces renal tubular injury and mitochondrial dysfunction in acute kidney injury partly by regulating the SIRT3/SOD2 pathway.

Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets

Rhein, a component of rhubarb, has both positive and negative effects on kidney function, with potential kidney toxicity at large dosages and long use times.

Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations.

Plant extracts, phytochemicals, and herbal formulations show potential in reducing acetaminophen-induced liver injury with fewer side effects and cost-effectiveness compared to synthetic drugs.