Rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma, in vitro and in vivo.

doi:10.1016/j.ijrobp.2013.12.051

Paper

Rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma, in vitro and in vivo.

Published Apr 1, 2014 · L. Agoni, I. Basu, Seema R. Gupta

International journal of radiation oncology, biology, physics

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26

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2

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Abstract

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In Vitro Study

Study Snapshot

Rigosertib is a more effective radiosensitizer than cisplatin for cervical carcinoma treatment, with minimal toxicity, supporting the need for clinical trials in combination therapy for cervical carcinoma patients.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma, in vitro and in vivo.

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References

Citations

Discovery of dual-targeted molecules based on Olaparib and Rigosertib for triple-negative breast cancer with wild-type BRCA.

Dual-targeted molecules based on Olaparib and Rigosertib show potential efficacy in treating triple-negative breast cancer with wild-type BRCA, offering a potential treatment option for these patients.

Manganese and copper-coated nickel oxide nanoparticles synthesized from Carica papaya leaf extract induce antimicrobial activity and breast cancer cell death by triggering mitochondrial caspases and p53

Manganese-copper-coated nickel oxide nanoparticles synthesized from Carica papaya leaf extract effectively inhibit breast cancer cell growth and induce apoptosis by triggering mitochondrial caspases and p53.

ceRNA networks in gynecological cancers progression and resistance

CeRNAs play a crucial role in gynecological cancer progression and resistance, potentially serving as therapeutic targets and predictive biomarkers.

Another Brick to Confirm the Efficacy of Rigosertib as Anticancer Agent

Rigosertib shows different efficacy depending on the cell line and could be a potential antineoplastic agent against lung cancer in humans.

Novel Implications of Nanoparticle-Enhanced Radiotherapy and Brachytherapy: Z-Effect and Tumor Hypoxia

Nanoparticle-enhanced radiotherapy and brachytherapy may reduce dose-related toxicity and alleviate tumor hypoxia, potentially improving radiation oncology outcomes.