Role of cell cycle events and apoptosis in mediating the anti-cancer activity of a silver(I) complex of 4-hydroxy-3-nitro-coumarin-bis(phenanthroline) in human malignant cancer cells.

doi:10.1016/j.ejphar.2008.11.020

Paper

Role of cell cycle events and apoptosis in mediating the anti-cancer activity of a silver(I) complex of 4-hydroxy-3-nitro-coumarin-bis(phenanthroline) in human malignant cancer cells.

Published Jan 14, 2009 · B. Thati, A. Noble, B. Creaven

European journal of pharmacology

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62

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Abstract

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In Vitro Study

Rigorous Journal

Study Snapshot

The silver(I) complex of 4-hydroxy-3-nitro-coumarin-bis(phenanthroline) is a more potent anti-proliferative agent than cisplatin, causing cell death through apoptosis and altering cell cycle progression.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Role of cell cycle events and apoptosis in mediating the anti-cancer activity of a silver(I) complex of 4-hydroxy-3-nitro-coumarin-bis(phenanthroline) in human malignant cancer cells.

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