Role of TLR4/MyD88/NF-κB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil.

doi:10.1016/j.biopha.2018.07.014

Paper

Role of TLR4/MyD88/NF-κB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil.

Published Oct 1, 2018 · Q. Su, Xiangwei Lv, Yu-han Sun

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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57

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Abstract

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Non-RCT

Animal Study

Rigorous Journal

Study Snapshot

Nicorandil effectively protects cardiomyocytes from coronary microembolization-induced myocardial injury by inhibiting TLR4/MyD88/NF-B signaling, improving cardiac function and reducing postoperative myocardial injury.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Role of TLR4/MyD88/NF-κB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil.

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References

Citations

Effects of Fisetin and Nicorandil on adjuvant-induced rheumatoid arthritis in rats: Emerging role of TLR4/NF-κB-induced Pyroptosis, Nrf-2/HO-1, and OPG/RANKL pathways.

Fisetin and nicorandil combined show better anti-rheumatic potential, suppressing oxidative stress and NF-B, and improving patient outcomes through TLR4/NF-B pyroptotic signaling, Nrf-2/HO-1, and OPG/RANKL pathways.

Research Progress of Regulatory Cell Death in Coronary Microembolization

Regulatory cell death plays a crucial role in coronary microembolization, influencing inflammation, oxidative stress, cell death, and angiogenesis, offering potential new avenues for prevention and treatment.

Bezafibrate mitigates cardiac injury against coronary microembolization by preventing activation of p38 MAPK/NF-κB signaling

Bezafibrate improves cardiac function and reduces myocardial injury after coronary microembolization by preventing p38 MAPK/NF-B signaling and reducing oxidative stress.

Transcriptomic Analysis of Cardiac Tissues in a Rodent Model of Coronary Microembolization

Disturbances in mitochondrial activity and metabolism are key mechanisms in coronary microembolization, and mitochondria-related genes may be potential therapeutic targets.

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Celastrol-nanomedicine, delivered through ROS-sensitive polymeric micelles, effectively alleviates inflammation in dry eye disease by inhibiting TLR4 signaling and reducing pro-inflammatory cytokine expression.