2-Iodoxybenzoic acid is a convenient reagent for the dehydrogenation of tetrahydro-β-carbolines to their aromatic forms under mild conditions. The utility of the method was demonstrated in a total synthesis of the marine indole alkaloid eudistomin U.

2-Iodoxybenzoic acid effectively dehydrogenates tetrahydro--carbolines to aromatic forms under mild conditions, aiding in the total synthesis of marine indole alkaloid eudistomin U.

Paper

Room-temperature aromatization of tetrahydro-β-carbolines by 2-iodoxybenzoic acid: utility in a total synthesis of eudistomin U.

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