Rubidium Shows Different Effects from Lithium on Phosphatidylinositol Metabolism in a Cell Line of Human Neuroblastoma

doi:10.1007/978-3-642-76646-6_26

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Rubidium Shows Different Effects from Lithium on Phosphatidylinositol Metabolism in a Cell Line of Human Neuroblastoma

Published 1993 · A. Spinedi, L. Pacini, P. Luly

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Abstract

Rubidium (Rb+) has been used for many years in the control of endogenous depression (Meltzer et al. 1969; Fieve et al. 1971; Fieve and Meltzer 1974; Sarteschi et al. 1984), despite the fact that its mechanism of action is still unknown. In fact, it has been found to produce therapeutic effect in 65% of patients with endogenous depression (Carolei et al. 1975); also in bipolar patients Rb+ was shown to decrease both the duration and severity of depressive episodes (Fieve 1976).

Study Snapshot

Rubidium shows different effects from lithium on phosphophatidylinositol metabolism in a human neuroblastoma cell line, suggesting a potential role in treating depression and bipolar disorder.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Rubidium Shows Different Effects from Lithium on Phosphatidylinositol Metabolism in a Cell Line of Human Neuroblastoma

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References

Inositol phosphates: a family of signal molecules?

Inositol phosphate metabolism provides cells with a family of signal molecules, each with a unique function, potentially playing a crucial role in controlling nervous system functions.

Exploration of the Clinical Profile of Rubidium Chloride in Depression: A Systematic Open Trial

Rubidium chloride shows promising clinical promise in improving depression in female inpatients, warranting further double-blind trials.

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NMDA receptors play a key role in brain plasticity, learning, and neurotoxicity, and their understanding has revolutionized our understanding of excitatory amino acids.

Acute and chronic lithium treatments influence agonist and depolarization-stimulated inositol phospholipid hydrolysis in rat cerebral cortex.

Acute and chronic lithium treatments severely disrupt phosphoinositide metabolism in rat cerebral cortex, potentially due to inhibition of inositol-monophosphatase, but these effects are not reversed by inositol.

Lithium and inositol lipid-linked signalling mechanisms

Lithium may treat manic disorders by interfering with inositol lipid metabolism, explaining its central selectivity and narrow therapeutic index.

The interaction of lithium ions with inositol lipid signalling systems.

Lithium ions selectively interfere with the inositol lipid cycle, potentially yielding valuable therapeutic agents for treating manic-depressive illness.

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In cerebellar granule cells, excitatory amino acid signaling is influenced by calcium, Mg2+, APV, and PCP, with quisqualate and kainate showing selective responses.

Inositol trisphosphate, a novel second messenger in cellular signal transduction

Inositol trisphosphate, a novel second messenger in cellular signal transduction, plays a crucial role in controlling various cellular processes, including secretion, metabolism, phototransduction, and cell proliferation.

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