Paper
Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action.
Published Feb 1, 2018 · Mojtaba Shafiee, S. Arekhi, Alireza Omranzadeh
Journal of affective disorders
Q1 SJR score
133
Citations
2
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Literature Review
Rigorous Journal
Highly CitedStudy Snapshot
Saffron may have antidepressant effects and is an efficacious and safe treatment for depression, anxiety, and other mental disorders with fewer side effects compared to current medications.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Crocus sativus L. versus Citalopram in the Treatment of Major Depressive Disorder with Anxious Distress: A Double-Blind, Controlled Clinical Trial
Saffron and citalopram both show significant improvements in depression and anxiety levels, with no significant difference in side effects between the two treatments.
2016·84citations·A. Ghajar et al.·Pharmacopsychiatry
Pharmacopsychiatry
Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial
Saffron may be a safe alternative medication for improving depressive symptoms of postpartum depression, but larger, longer-term studies are needed for confirmation.
2016·77citations·L. Kashani et al.·Pharmacopsychiatry
Pharmacopsychiatry
Study the effects of saffron on depression and lipid profiles: A double blind comparative study.
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Asian journal of psychiatry
A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression
Saffron supplements significantly improve anxiety and depression symptoms, with rare side effects, after 12 weeks of treatment.
2016·102citations·M. Mazidi et al.·Journal of Complementary and Integrative Medicine
Journal of Complementary and Integrative Medicine
Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial
Dried extract of saron at 25 mg dose is more effective in reducing pre-herniorrhaphy surgery anxiety compared to diazepam.
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Zahedan Journal of Research in Medical Sciences
Citations
Therapeutic Potential of Saffron Extract in Mild Depression: A Study of Its Role on Anhedonia in Rats and Humans.
Saffron extract shows potential in reducing anhedonia and improving motivation in mild depression, potentially through modulation of dopaminergic transmission and BDNF-TrkB signaling.
2025·0citations·Eleonora Corridori et al.·Phytotherapy research : PTR
Phytotherapy research : PTR
Spray drying of saffron extract-loaded coacervates by carboxymethyl cellulose/maltodextrin/saffron petal anthocyanins
The active/dual encapsulation system significantly improves the retention of saffron bioactive compounds, potentially benefiting other bioactive components.
2025·0citations·Hamid Rajabi et al.·Carbohydrate Polymer Technologies and Applications
Carbohydrate Polymer Technologies and Applications
Medicinal plants and plant-based traditional medicine: Alternative treatments for depression and their potential mechanisms of action
Medicinal plants and plant-based traditional medicine show potential as effective, safe, and affordable alternatives to antidepressants for psychiatric disorders.
2024·0citations·Juwairiah Remali et al.·Heliyon
Heliyon
Exploring the Potential of Saffron as a Therapeutic Agent in Depression Treatment: A Comparative Review
Saffron shows potential as an effective and safer alternative to standard depression treatments, with potential benefits matching those of standard medications and offering antioxidant benefits.
2024·0citations·Satendra Chauhan et al.·The Yale Journal of Biology and Medicine
The Yale Journal of Biology and Medicine
Bioinformatic analysis of the molecular targets of curcumin in colorectal cancer.
Curcumin may have beneficial effects on colorectal cancer by modulating multiple susceptibility genes and critical signaling pathways.
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Pathology, research and practice
Borneol and lactoferrin dual-modified crocetin-loaded nanoliposomes enhance neuroprotection in HT22 cells and brain targeting in mice.
Crocetin-loaded nanoliposomes with borneol and lactoferrin dual-modification show potential for brain-targeted delivery and neuroprotection after intranasal administration.
2024·1citation·Zheren Tong et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Effect of Saffron Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment of Depression and Anxiety: A Meta-analysis of Randomized Controlled Trials.
Saffron may be a potential SSRI alternative for reducing depressive and anxiety symptoms with fewer adverse events.
2024·2citations·Arman Shafiee et al.·Nutrition reviews
Nutrition reviews