Antimycotic sensitivity evaluation against Candida ATCC species of 1,2,3-triazoles derived from 5-chloro-2(2,4-dichlorophenoxy)phenol

doi:10.1007/s00044-019-02490-7

Paper

Antimycotic sensitivity evaluation against Candida ATCC species of 1,2,3-triazoles derived from 5-chloro-2(2,4-dichlorophenoxy)phenol

Published Dec 17, 2019 · DOI · Cristian A. Pastrana-Gómez, C. C. Almonacid-Urrego, Bayardo E. Velasco-Montejo

Medicinal Chemistry Research

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Abstract

Antifungal activity against four yeast of Candida genus of four 1,2,3-triazoles derived from 5-chloro-2(2,4-dichlorophenoxy)phenol, were evaluated in vitro, determining its minimum inhibitory concentration and susceptibility criteria. Strains were exposed to concentrations of 16–0.03 µg/ml, of the four triazoles, following the microplate microdilution technique, using Fluconazole as antifungal control. In all cases 4-[5-Chloro-2-(2,4-dichloro-phenoxy)-phenoxymethyl]-1-(3,4-dichloro-phenyl)-1,2,3-triazole showed the lowest MICs. The four tested triazole derivatives show an effective antifungal effect in vitro in the strains of Candida ATCC, for which it is recommended to carry out microbiological studies in vivo to ensure the efficacy of these compounds in fungal infections developed by Candida spp.

In Vitro Study

Study Snapshot

Four 1,2,3-triazoles derived from 5-chloro-2(2,4-dichlorophenoxy)phenol show effective antifungal activity against Candida ATCC yeast strains in vitro, warranting further in vivo studies for potential use in fungal infections.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Antimycotic sensitivity evaluation against Candida ATCC species of 1,2,3-triazoles derived from 5-chloro-2(2,4-dichlorophenoxy)phenol

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