Paper

Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice.

Published May 1, 2016 · Yuki Yasumoto, Chiaki Hashimoto, R. Nakao

Metabolism: clinical and experimental

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Abstract

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Non-RCTAnimal StudyHighly Cited

Study Snapshot

Feeding at unusual times of the day (inactive phase) leads to obesity and metabolic disorders by inducing leptin resistance, hyperphagia, physical inactivity, hepatic fat accumulation, and adiposity in mice.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice.

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