Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH3)2}2mu-dpzm]2+ and its implications for anticancer drug delivery.

doi:10.1016/j.jinorgbio.2008.12.011

Paper

DOI: 10.1016/j.jinorgbio.2008.12.011

Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH3)2}2mu-dpzm]2+ and its implications for anticancer drug delivery.

Published Mar 1, 2009 · N. Wheate, Gráinne M Abbott, R. Tate

Journal of inorganic biochemistry

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Abstract

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In Vitro Study

Study Snapshot

P-sulphonatocalix[4]arene shows potential as a drug delivery vehicle for multinuclear platinum anticancer agents, with no cytotoxicity at up to 1.5 mM and no effect on di-Pt cytotoxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1021/ic800467c

Substituted beta-cyclodextrin and calix[4]arene as encapsulatory vehicles for platinum(II)-based DNA intercalators.

Encapsulation of platinum(II)-based anticancer complexes in c-beta-CD or s-CX[4] protects them from degradation and increases their stability, potentially improving their anticancer activity.

2008·73citations·A. Krause-Heuer et al.·Inorganic chemistry

Inorganic chemistry

DOI: 10.1039/B718962A

Toxicity and biodistribution of para-sulfonato-calix[4]arene in mice

Para-35S-sulfonato-calix[4]arene shows no acute toxicity in mice and rapidly clears in urine, with no accumulation in liver, spleen, or brain.

2008·143citations·A. Coleman et al.·New Journal of Chemistry

New Journal of Chemistry

DOI: 10.1021/jm7016072

Degradation of bidentate-coordinated platinum(II)-based DNA intercalators by reduced L-glutathione.

Reduced L-glutathione and L-methionine degrade bidentate-coordinated platinum(II)-based DNA intercalators, with the degradation rate inversely correlated to cytotoxicity, and cucurbit[n]urils can stop the degradation process.

2008·70citations·S. Kemp et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1021/jm070813z

Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity.

Acetyl-protected spermidine-bridged dinuclear platinum complexes show potential as potent antitumor agents with DNA binding similar to the Boc derivative, but differences in cytotoxicity and cell line specificity may contribute to observed behavior.

2008·31citations·A. Hegmans et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1021/jp709847p

Examination of cucurbit[7]uril and its host-guest complexes by diffusion nuclear magnetic resonance.

Cucurbit[7]uril (CB[7]) partially self-associates in D2O, affecting the diffusion of various inorganic and organic guests, and encapsulation within CB[7] decreases their rates of diffusion in D2O.

2008·39citations·N. Wheate et al.·The journal of physical chemistry. B

The journal of physical chemistry. B

Citations

DOI: 10.1016/j.ccr.2024.216147

Utilizing the metal coordination and supramolecular chemistry of macrocycles to tackle medicinal issues

Macrocylic metal-based agents show promise in improving cancer drug delivery and effectiveness, as well as tackling bacteria, TB, and HIV, with potential applications in nanoparticles.

2025·0citations·Carl Redshaw·Coordination Chemistry Reviews

Coordination Chemistry Reviews

DOI: 10.3390/molecules28196954

Functionalized Calixarenes as Promising Antibacterial Drugs to Face Antimicrobial Resistance

Functionalized calixarenes show promise as promising antibacterial drugs to combat antimicrobial resistance due to their ability to precisely tune their geometry and regioselective polyfunctionalization.

2023·9citations·M. Mourer et al.·Molecules

Molecules

DOI: 10.1080/10610278.2022.2073823

Aqueous compatibility of 15 pharmaceutical antimicrobial preservatives with the macrocycles cucurbit[7]uril and para-sulfonatocalix[4]arene

Eight preservatives are compatible with both cucurbit[7]uril and para-sulfonatocalix[4]arene, while benzalkonium chloride, cetrimide, and chlorhexidine are incompatible with both macrocycles.

2021·1citation·Xenia L. Nastatos et al.·Supramolecular Chemistry

Supramolecular Chemistry

DOI: 10.1039/d1ra04614d

Betaine host–guest complexation with a calixarene receptor: enhanced in vitro anticancer effect

The host-guest complexation of betaine with p-SC4 increases its concentration in cancer cells, warranting further investigation for cancer therapy.

2021·18citations·S. Fahmy et al.·RSC Advances

RSC Advances

DOI: 10.1007/s10847-021-01096-0

Comparative host–guest complex formation of the Alzheimer’s drug memantine with para-sulfonatocalix[n]arenes (n = 4 or 8)

Memantine forms subtly different host-guest complexes with different sized para-sulfonatocalix[n]arenes, which could be used to tune the drug delivery potential for different pharmaceutical applications.

2021·0citations·N. Wheate·Journal of Inclusion Phenomena and Macrocyclic Chemistry

Journal of Inclusion Phenomena and Macrocyclic Chemistry

DOI: 10.1007/s11224-021-01794-y

Tuning the antioxidant property of potential calixdrug calix[4]tyrosol: role of aza and thia linkages

Aza-calix[4]tyrosol, a novel antioxidant system, shows the finest antioxidant property among calix[4]aromatics, with potential as a calixdrug and radical scavenger.

2021·4citations·Rakiba Rohman et al.·Structural Chemistry

Structural Chemistry

DOI: 10.1007/s10847-021-01055-9

Macrocycles as drug-enhancing excipients in pharmaceutical formulations

Macrocycles show potential as drug-enhancing excipients in pharmaceutical formulations, offering benefits such as increased drug solubility, taste masking, controlled release, improved stability, and light activation of prodrugs.

2021·45citations·Alice Gu et al.·Journal of Inclusion Phenomena and Macrocyclic Chemistry

Journal of Inclusion Phenomena and Macrocyclic Chemistry

DOI: 10.3390/molecules25245926

Host-Guest Complexation of Oxaliplatin and Para-Sulfonatocalix[n]Arenes for Potential Use in Cancer Therapy

Oxaliplatin and p-sulfonatocalix[n]arenes host-guest complexes show potential for improved solubility, stability, and bioavailability in cancer therapy, warranting further investigation for cancer therapy.

2020·29citations·S. Fahmy et al.·Molecules

Molecules

DOI: 10.1021/acsomega.0c05168

Experimental and Computational Investigations of Carboplatin Supramolecular Complexes

Carboplatin supramolecular complexes with p-4-sulfocalix[n]arenes show stronger anticancer activities against breast adenocarcinoma and lung cancer cells compared to free carboplatin, suggesting potential use in cancer therapy.

2020·25citations·S. Fahmy et al.·ACS Omega

ACS Omega