A simple one-pot synthesis of cyclopropane [11C]carbonyl chloride. Synthesis and biodistribution of [11C]cyclorphan†

doi:10.1002/jlcr.2580230507

Paper

A simple one-pot synthesis of cyclopropane [11C]carbonyl chloride. Synthesis and biodistribution of [11C]cyclorphan†

Published May 1, 1986 · DOI · D. McPherson, D. Hwang, J. Fowler

Journal of Labelled Compounds and Radiopharmaceuticals

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Abstract

A rapid, one-pot, synthesis of cyclopropane [11C]carbonyl chloride was developed. This synthesis proceeded in 80% radiochemical yield (EOB) in a synthesis time of 10 minutes. This acid chloride was then used to synthesize a model compound, [11C]cyclorphan, by alkylation of norlevorphanol followed by reduction of the intermediate [11C]amide in an overall synthesis time of 55 minutes and a radiochemical yield of 15% (EOB). The biodistribution of [11C]cyclorphan in control and naloxone pretreated mice showed non-specific binding and rapid clearance from brain.

Non-RCTAnimal Study

Study Snapshot

This one-pot synthesis of cyclopropane [11C]carbonyl chloride allows for the rapid synthesis of [11C]cyclorphan, a model compound with non-specific binding and rapid clearance from the brain.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

A simple one-pot synthesis of cyclopropane [11C]carbonyl chloride. Synthesis and biodistribution of [11C]cyclorphan†

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