Paper

Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation.

Published Nov 11, 2016 · Nagendra Yaluri, S. Modi, T. Kokkola

Biochemical and biophysical research communications

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Abstract

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In Vitro Study

Study Snapshot

Simvastatin impairs insulin secretion and sensitivity by suppressing insulin signaling, GLUT4 expression, and GSK-3 phosphorylation, contributing to insulin resistance in skeletal muscle myotubes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation.

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