Paper

Simvastatin inhibits glucose uptake activity and GLUT4 translocation through suppression of the IR/IRS-1/Akt signaling in C2C12 myotubes.

Published Oct 1, 2016 · Weihua Li, Xiaojing Liang, Zhipeng Zeng

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro StudyRigorous Journal

Study Snapshot

Simvastatin inhibits glucose uptake and GLUT4 translocation in C2C12 myotubes through suppression of the insulin receptor/IRS-1/Akt pathway, potentially increasing the risk of new-onset diabetes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Simvastatin inhibits glucose uptake activity and GLUT4 translocation through suppression of the IR/IRS-1/Akt signaling in C2C12 myotubes.

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