Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to characterize the vasodilatory effects of topically applied MN and to study the involvement of nitric oxide (NO), local sensory nerves, and prostaglandin‐mediated pathways.

Topically applied methyl nicotinate induces local cutaneous erythema in the skin, potentially affecting microcirculation and skin viability through nitric oxide, local sensory nerves, and prostaglandin-mediated pathways.

Paper

Skin blood flow response to topically applied methyl nicotinate: Possible mechanisms

References

Citations