Summary The therapeutic effects of sodium sulfadiazine upon Amblystoma embryos, following surgical interruption of the central nervous system, are described. Embryos which may undergo 100% mortality when sterile technic is not employed, will survive when treated for 2 days with a 1% aqueous solution of the drug. There is no evidence of any toxic effect. Treated embryos undergo normal development and at a rate parallel with control embryos kept at the same temperature. Minimum concentrations of the drug as well as minimum length of treatment necessary to insure survival remain to be determined.

Sodium sulfadiazine treatment for 2 days after central nervous system surgery on Amphibian embryos results in survival and normal development without toxic effects.

Paper

On the Use of Sodium Sulfadiazine in Surgery on Amphibian Embryos

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