Sodium thiophene carboxylate does not facilitate expectoration.

doi:10.1183/09031936.93.04060718

Paper

Sodium thiophene carboxylate does not facilitate expectoration.

Published Jun 1, 1991 · E. Streit, TC Medici

The European respiratory journal

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Abstract

A randomised double-blind crossover study compared the clinical effectiveness of a 21-day treatment with 600 mg per day of sodium thiophene carboxylate and placebo in 33 patients with stable chronic bronchial disease. During the seven week trial, subjective symptoms and findings were recorded, pulmonary function tests performed and sputum physical characteristics determined. Side-effects were closely monitored. Both subjective assessment of overall clinical efficacy and statistical analysis of the above mentioned factors failed to show any significant advantage of sodium thiophene carboxylate to placebo. Sodium thiophene carboxylate appears to be an expectorant and mucoregulatory drug, lacking evidence of clinical effectiveness in the treatment of patients with stable chronic bronchitis.

RCT

Study Snapshot

Sodium thiophene carboxylate lacks clinical effectiveness in treating stable chronic bronchitis patients.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Sodium thiophene carboxylate does not facilitate expectoration.

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References

Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases.

Oral acetylcysteine significantly reduces exacerbation rates in chronic bronchitis patients, with 40% remaining free from exacerbations compared to 19% in the placebo group.

The two-period cross-over clinical trial.

Cross-over clinical trials offer more precise treatment comparisons, but require fewer subjects for the same precision.

Quantitation of sputum protein by use of the biuret reaction.

The biuret reaction method accurately quantifies sputum protein content, comparing favorably with the microKjeldahl technique and being fast and reproducible.

New objective criteria for inflammation in bronchial secretions.

Objective criteria for evaluating improvement or aggravation of chronic bronchitis in bronchial secretions are needed.

The National Mucolytic Study. Results of a randomized, double-blind, placebo-controlled study of iodinated glycerol in chronic obstructive bronchitis.

Iodinated glycerol significantly improves symptoms and reduces acute exacerbations in chronic obstructive bronchitis patients, but not dyspnea.

Citations