Paper
Some pharmacological and toxicological properties of several phthalimidoaldehydes.
Published May 1, 1968 · A. Burkman, G. Ringham, M. H. Weinswig
Journal of pharmaceutical sciences
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Abstract
Four phthalimidoaldehyde derivatives were prepared and several parameters of pharmacological activity were examined: acute toxicity, coordination deficit, ability to alter barbiturate-induced “sleep” in mice, provoke lacrimation and chromodacryorrhea in rats, and influence contractility of excised guinea pig ileum. Gammaphthalimidobutyraldehyde and α-phthalimido-β-methylbutyraldehyde, the more toxic members of the group, significantly prolonged hexobarbital sleep time. The most intense lacrimatory effects were produced by α-phthalimido-β-methylbutyraldehyde while the most pronounced contractile response in isolated gut was provoked by phthalimidoacetaldehyde. The two latter responses were blocked by atropine premedication. None of the compounds produced chromodacryorrhea.
Phthalimidoaldehydes can prolong sleep time, cause intense lacrimation, and affect gut contractility, but none produce chromodacryorrhea.
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