The chemical properties of 2-chloro-3-(β-chloroethyl)-4,6-dihydroxypyridine (I) have been studied. It has been shown that this compound, which is relatively stable in acids and in neutral and, particularly, in alkaline media, readily splits off hydrogen chloride under mild conditions and is converted into derivatives of 2, 3-dihydro-5-azabenzofuran. The dehalogenation of I in an acid medium yielded 3-(β-chloroethyl)-4, 6-dihydroxypyridine, which was converted into 4, 6-dichloro-3-(β-chloroethyl)pyridine and into 6-chloro-4-methoxy-3-vinylpyridine.

2-chloro-3-(-chloroethyl)-4,6-dihydroxypyridine (I) is a stable compound that readily splits off hydrogen chloride under mild conditions and can be converted into derivatives of 2, 3-dihydro-5-azabenzofuran.

Paper

Some reactions of 2-chloro-3-(β-chloroethyl)-4,6-dihydroxypyridine

References

Citations