Some substitution reactions of thieno[3,4-b]thiophene and methyl thieno[3;4-b]thiophene-2-carboxylate

doi:10.1002/RECL.19700890112

Paper

Some substitution reactions of thieno[3,4-b]thiophene and methyl thieno[3;4-b]thiophene-2-carboxylate

Published Sep 2, 2010 · H. Wynberg, J. Feijen

Recueil des Travaux Chimiques des Pays-Bas

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Abstract

The formylation of thieno[3,4-b]thiophene gives a mixture of 4-formyl- and 6-formyl-thieno[3,4-b]thiophene in a ratio of 70 : 30. Lithiation followed by formylation of the resulting organolithium compounds changes this ratio to 20 : 80. The formylation of methyl thieno[3,4-b]thiophene-2-carboxylate has been shown to give the 4- and 6-substituted isomers in a 50 : 50 ratio. The structures of the substitution products were established by oxidation and desulfurization experiments and by PMR spectroscopy.

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Formylation of thieno[3,4-b]thiophene produces a mixture of 4-formyl- and 6-formyl-thieno[3,4-b]thiophene in a 70:30 ratio, while formylation of methyl thieno[3,4-

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Some substitution reactions of thieno[3,4-b]thiophene and methyl thieno[3;4-b]thiophene-2-carboxylate

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References

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The proton magnetic resonance spectra of benzofuran, dibenzofuran, indole, 7-azaindole, carbazole, and 4-azacarbazole reveal cross-ring coupling constants involving the NH proton of indole and carbazole.

Synthesen in der Polymyxin-Reihe 2. Mitteilung. Synthese eines Dipeptid-Fragmentes mit (+)-Isopelargonsäure

This study successfully synthesized (+)-6-methylloctanoic (isopelargonic) acid, a key component of polymyxin antibiotics, using a new route and known peptide coupling methods.

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