Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

doi:10.1016/s0021-9258(18)67133-9

Paper

DOI: 10.1016/s0021-9258(18)67133-9

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

Published Sep 25, 1986 · Y. Hannun, C. Loomis, A. Merrill

The Journal of biological chemistry

Q1 SJR score

984

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Highly Cited

Study Snapshot

Sphingosine inhibits protein kinase C activity and phorbol dibutyrate binding, potentially playing a physiological role as a negative effector in platelets and other cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Full text analysis coming soon...

References

No references found

Citations

DOI: 10.47895/amp.vi0.7600

Effects of Apis dorsata Honey on the mRNA Expression of Selected CYP450, Pro-apoptotic, and Anti-apoptotic Genes during Induced Cytotoxicity in Cyclophosphamide-treated Human Lung Carcinoma (A549) Cells

A. dorsata honey enhances the cytotoxic effect of cyclophosphamide in human lung carcinoma cells by upregulating CYP450 genes and promoting apoptosis through upregulation of CASP8 and downregulation of BCL2.

2024·1citation·Jay T. Dalet et al.·Acta Medica Philippina

Acta Medica Philippina

DOI: 10.1016/j.jlr.2024.100683

Orm proteins control ceramide synthesis and endocytosis via LCB-mediated Ypk1 regulation

Yeast Orm proteins play a complex role in regulating ceramide synthesis and endocytosis through regulating Ypk1 signaling through long chain bases.

2024·0citations·Jihui Ren et al.·Journal of Lipid Research

Journal of Lipid Research

DOI: 10.1016/j.colsurfb.2024.114155

(1-Deoxy)ceramides in bilayers containing sphingomyelin and cholesterol.

(1-deoxy)ceramides show lower miscibility in sphingomyelin/cholesterol bilayers, potentially impacting the pathogenesis of sphingolipid-related diseases like neuropathies, diabetes, and glycogen storage diseases.

2024·0citations·E. González-Ramírez et al.·Colloids and surfaces. B, Biointerfaces

Colloids and surfaces. B, Biointerfaces

DOI: 10.7554/eLife.89938

Membrane contact sites regulate vacuolar fission via sphingolipid metabolism

Membrane contact sites maintain vacuolar morphology through the metabolism of sphingolipids, regulating vacuolar fission in yeast.

2024·1citation·Kazuki Hanaoka et al.·eLife

eLife

DOI: 10.3390/life13020510

Involvement of Lipids in the Pathogenesis of Amyotrophic Lateral Sclerosis

ALS pathogenesis involves alterations in lipid metabolism, with sphingolipids playing a key role in neuroinflammatory and immune responses, and potential new drugs targeting lipid metabolism enzymes.

2023·2citations·A. Alessenko et al.·Life

Life

DOI: 10.1016/j.bbrc.2022.08.074

Sphingomyelin: What is it good for?

Sphingomyelin plays a diverse role in maintaining membrane order, regulating cell signaling and apoptosis, and forming clusters with cholesterol and ceramide.

2022·30citations·F. Goñi·Biochemical and biophysical research communications

Biochemical and biophysical research communications

DOI: 10.3390/ijms232112745

Advancements on the Multifaceted Roles of Sphingolipids in Hematological Malignancies

Sphingolipids, such as ceramide, play a complex role in hematological malignancies, and their use in therapeutic regimens can enhance anti-leukemic effects and reduce resistance to standard therapies.

2022·1citation·Yasharah Raza et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences

DOI: 10.3390/cells11182914

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

Ablation of SphK1 significantly reduces corneal neovascularization after injury, suggesting a role for S1P in post-injury corneal neovascularization.

2022·4citations·Joseph L. Wilkerson et al.·Cells

Cells

DOI: 10.3390/ijms23169255

Targeting the Sphingolipid Rheostat in Gliomas

Targeting the sphingolipid rheostat in gliomas can enhance tumor cell death and improve survival rates by altering the balance between pro-apoptotic ceramides and pro-survival S1P signaling.

2022·18citations·Faris Zaibaq et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences