Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action.

doi:10.1016/j.jep.2016.03.003

Paper

DOI: 10.1016/j.jep.2016.03.003

Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action.

Published May 26, 2016 · B. Chindo, H. Schröder, A. Koeberle

Journal of ethnopharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Standardized methanol stem bark extract of Ficus platyphylla shows analgesic properties and inhibits COX-2 and 5-LO, supporting its use in Nigerian folk medicine for pain treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1097/j.pain.0000000000000176

Cerebral analgesic response to nonsteroidal anti-inflammatory drug ibuprofen

Ibuprofen has a measurable analgesic response in the human brain, with its subjective effects reflecting two distinct brain networks.

2015·42citations·D. Hodkinson et al.·PAIN

PAIN

DOI: 10.1007/s12017-015-8351-0

A Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase Protects Against Kainic Acid-Induced Brain Injury

Dual inhibition of COX/5-LOX by flavocoxid has neuroprotective effects during kainic acid-induced excitotoxicity, reducing inflammation and apoptosis in the brain.

2015·28citations·L. Minutoli et al.·NeuroMolecular Medicine

NeuroMolecular Medicine

DOI: 10.3389/fncel.2015.00135

Cross-talk and regulation between glutamate and GABAB receptors

GABAB receptors play a crucial role in modulating brain excitability by directly influencing glutamate receptors, impacting neurotransmission, pain pathways, and various psychiatric and neurodegenerative diseases.

2015·59citations·S. Kantamneni·Frontiers in Cellular Neuroscience

Frontiers in Cellular Neuroscience

DOI: 10.1016/j.bbalip.2014.08.012

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease.

5-Lipoxygenase plays a key role in leukotriene biosynthesis, which plays a role in both normal host defense and various diseases involving acute or chronic inflammation.

2015·418citations·O. Rådmark et al.·Biochimica et biophysica acta

Biochimica et biophysica acta

DOI: 10.1016/j.phymed.2014.10.005

Methanol extract of Ficus platyphylla ameliorates seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice.

Methanol extract of Ficus platyphylla stem bark effectively reduces seizure severity, cognitive deficits, and neuronal cell loss in mice with pentylenetetrazole-induced epilepsy.

2015·19citations·B. Chindo et al.·Phytomedicine : international journal of phytotherapy and phytopharmacology

Phytomedicine : international journal of phytotherapy and phytopharmacology

Citations

DOI: 10.21926/obm.neurobiol.2304200

Effects of Ficus Platyphylla-Induced Hypothermia on Long-term Functional Recovery after Ischaemic Stroke

Ficus platyphylla-induced hypothermia may improve long-term functional recovery after ischaemic stroke, with smaller infarct sizes observed in mice treated with the treatment.

2023·0citations·Axel Becker et al.·OBM Neurobiology

OBM Neurobiology

DOI: 10.33003/fjs-2023-0705-1973

PHYTOCHEMICAL CONSTITUENTS AND INVITRO FREE RADICAL SCAVENGING ACTIVITIES OF METHANOL EXTRACT AND FRACTIONS OF Ficus platyphylla LEAVES (MORACEAE)

Methanol extract, n-Butanol, and ethyl acetate fractions of Ficus platyphylla leaves show the most effective free radical scavenging activities, potentially aiding in oxidative stress management in mammals.

2023·1citation·U. Shemishere et al.·FUDMA JOURNAL OF SCIENCES

FUDMA JOURNAL OF SCIENCES

DOI: 10.1155/2022/6349332

LC-MS and GC-MS Profiling of Different Fractions of Ficus platyphylla Stem Bark Ethanolic Extract

Ficus platyphylla stem bark ethanolic extract contains phytochemicals with potential pharmacological activity in managing pathological conditions.

2022·9citations·Madinat Hassan et al.·Journal of Analytical Methods in Chemistry

Journal of Analytical Methods in Chemistry

DOI: 10.33448/rsd-v11i12.34135

Ficus spp.: Phytochemical composition and medicinal potential

Ficus species show potential in pharmacological industry due to their antioxidant, antimicrobial, and anti-inflammatory properties, with potential applications in cosmetics, food, and pharmacology.

2022·2citations·J. M. A. Cruz et al.·Research, Society and Development

Research, Society and Development

DOI: 10.4314/njbas.v29i2.7

Methanol Stem Bark Extract of Ficus platyphylla Protects Against Carbon Tetrachloride-Induced Liver Damage in Wistar Rats

Methanol stem bark extract of Ficus platyphylla may offer protection against carbon tetrachloride-induced liver damage in Wistar rats by increasing enzyme activities and reducing ALT and AST levels.

2022·0citations·C. Ugwah-Oguejiofor et al.·Nigerian Journal of Basic and Applied Sciences

Nigerian Journal of Basic and Applied Sciences