A one step preparation of the n.c.a. fluorine-18 labelled synthons : 4-fluorobromobenzene and 4-fluoroiodobenzene

doi:10.1016/0969-8043(94)90155-4

Paper

DOI: 10.1016/0969-8043(94)90155-4

A one step preparation of the n.c.a. fluorine-18 labelled synthons : 4-fluorobromobenzene and 4-fluoroiodobenzene

Published 1994 · R. Gail, H. Coenen

Applied Radiation and Isotopes

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Abstract

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Study Snapshot

This study demonstrates a one-step preparation of fluorine-18 labelled synthons 4-fluorobromobenzene and 4-fluoroiodobenzene with radiochemical yields of 50-80% within 5 minutes using dimethyl acetamide as a solvent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Radiosynthesis of (S)-[18F]T1: The first PET radioligand for molecular imaging of α3β4 nicotinic acetylcholine receptors.

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4-[18F]Fluorophenylpiperazines by Improved Hartwig-Buchwald N-Arylation of 4-[18F]fluoroiodobenzene, Formed via Hypervalent λ3-Iodane Precursors: Application to Build-Up of the Dopamine D4 Ligand [18F]FAUC 316

This study successfully synthesized 4-[18F]fluorophenylpiperazines using a two-step process, resulting in the highly selective dopamine D4 ligand [18F]FAUC 316.

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Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodonium Salts

Copper-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts allows for rapid and regioselective synthesis of protected versions of important radiotracers.

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Automated radiosynthesis of no-carrier-added 4-[18F]fluoroiodobenzene ([18F]FIB) allows for high radiochemical and chemical purity, enabling versatile 18F radiochemistry reactions.

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Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers

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