Paper
Synthetic Strategies and Pharmacology of 2-Oxo-3-cyanopyridine Derivatives: A Review
Published Apr 27, 2015 · P. Ghosh, K. Manna, U. Banik
ChemInform
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Abstract
Heterocyclic compounds are widely distributed in nature and have biological and industrial significance. Already most of the drugs available in the market are heterocyclic in nature. Cyanopyridine, a structural motif has been a cause of concern for biologists’ and chemists’ for the last twenty years. Specifically 2-oxo-3-cyanopyridine scaffold demand importance due to their diverse, promising biological activities like anticancer, antibacterial, antifungal, sedative, cardiotonic agents, and HIV-1 non-nucleoside reverse transcriptase inhibitors. Due to high reactivity of this scaffold, it has been found asa reactive chemical intermediates invarious organic synthesis. In this short review we tried to focus on the recent development in synthesis of 2-oxo-3-cyanopyridine derivatives and all possible pharmacology reported for this compound. This review might be helpful for medicinal chemist in research regarding 2-oxo-3-cyanopyridine in future.
Recent developments in synthesis of 2-oxo-3-cyanopyridine derivatives show promise for diverse biological activities, including anticancer, antibacterial, antifungal, sedative, cardiotonic agents, and HIV-1 non-nucleoside reverse transcriptase inhibitors.
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