The crystal structure of 1-benzyl-4-(5,6-dimethoxy-1H-2-indenylmethyl)piperidine, C24H29O2N, has been determined. The compound crystallizes from methanol solvent in the monoclinic system, space group P21 with the following unit-cell parameters: a=10.245(8), b=5.523(4), c=18.670(2)A, β=102.472(7)°, Z=2, V=1031.5(16)A3. The crystal structure was solved by direct methods and refined by full-matrix least squares to a final R-value of 0.050 with 3751 unique reflections.

1-Benzyl-4-(5,6-dimethoxy-1H-2-indenylmethyl)piperidine crystallizes from methanol in a monoclinic system, providing insights into the synthesis of donapezil impurities.

Paper

Crystal Structure and Synthesis of 1-Benzyl-4-(5,6-dimethoxy-1H-2-indenylmethyl)piperidine, a Donapezil Impurity

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