Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.

doi:10.1016/j.bmc.2012.09.037

Paper

Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.

Published Nov 15, 2012 · N. Fushimi, H. Fujikura, H. Shiohara

Bioorganic & medicinal chemistry

Q2 SJR score

17

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1

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Abstract

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Non-RCT

Animal Study

Study Snapshot

4-benzyl-1H-pyrazol-3-yl -d-glucopyranoside derivatives show potent and selective SGLT1 inhibitory activity, suppressing postprandial hyperglycemia in diabetic rats.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.

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