A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities.

doi:10.1016/j.ejmech.2013.06.051

Paper

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities.

Published Sep 1, 2013 · Hriday Bera, B. Tan, Lingyi Sun

European journal of medicinal chemistry

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26

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Abstract

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In Vitro Study

Study Snapshot

The 5-thioxo analogues of 1,2,4-triazolo[1,5-a][1,3,5]triazine show varying inhibitory activity against thymidine phosphorylase and show anti-angiogenic effects in MDA-MB-231 breast cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities.

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