Paper

Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors.

Published Mar 1, 2016 · H. Ohno, Daiki Minamiguchi, Shinya Nakamura

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Modified 4-(thiazol-5-yl)benzoic acid derivatives show potent protein kinase CK2 inhibitory activities and antiproliferative properties three to six times higher than their parent compound.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors.

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