Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.

doi:10.1016/J.BMC.2003.10.041

Paper

Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.

Published Feb 1, 2004 · K. Jung, Soo-Kyung Kim, Zhang-Guo Gao

Bioorganic & medicinal chemistry

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115

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0

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Abstract

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In Vitro Study

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Study Snapshot

The most potent adenosine A3 receptor antagonist, N-[3-(4-methoxy-phenyl)-[1,2,4]thiadiazol-5-yl]-acetamide (39) shows antagonistic property in cAMP biosynthesis and shows potential binding mechanisms in aden

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.

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