Paper

SAR studies of 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one as inhibitors of 4-hydroxyphenylpyruvate dioxygenase.

Published Mar 1, 2002 · yung-lung Lin, Chung-Shieh Wu, Shean-Woei Lin

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

3-cyclopropanecarbonyloxy-2-cyclohexen-1-one derivatives show potential as inhibitors of 4-hydroxyphenylpyruvate dioxygenase, with 2-chloro substituted 12 being the most potent with a 15 nM IC50.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

SAR studies of 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one as inhibitors of 4-hydroxyphenylpyruvate dioxygenase.

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