Paper
Studies on antiatherosclerotic agents. VII. Synthesis and structure-activity relationship of 4-hydroxymethyl-1(2H)-phthalazinone derivatives.
Published Sep 25, 1980 · Y. Eguchi, A. Sugimoto, M. Ishikawa
Chemical & pharmaceutical bulletin
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Abstract
4-Hydroxymethyl-1(2H)-phthalazinone derivatives were synthesized and assayed for their inhibitory effects on platelet aggregation and edematous arterial reaction. Among the tested compounds, 7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone showed the highest potency in these pharmacological tests. The structure-activity relationship of phthalazinone derivatives and related compounds is discussed.
In Vitro Study7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone shows the highest potency in inhibiting platelet aggregation and edematous arterial reaction, offering potential as antiatherosclerotic agents.
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