Paper
Studies on antianaphylactic agents. 4. Synthesis and structure-activity relationships of 3-(4-oxo-4H-1-benzopyran-3)acrylic acids, a new series of antiallergic substances, and some related compounds.
Published Jan 1, 1975 · DOI · A. Noara, H. Kuriki, T. Saijo
Journal of medicinal chemistry
46
Citations
0
Influential Citations
Abstract
The syntheses of trans-3-(4-oxo-4H-1-benzypyran-3)acrylic acid and a number of analogs shown to be highly active in antiallergic bioassays are described. These compounds are of possible value in the treatment of asthma. The structural requirements for biological activity are discussed with reference to the type of the substituents on the chromone ring or positions of linkage of the acrylic acid on the pyrone ring.
3-(4-oxo-4H-1-benzopyran-3)acrylic acids show potential in treating asthma, with their structure-activity relationships influenced by substituent types and linkage positions.
Full text analysis coming soon...