1) 10-(Dimethylaminomethyl) -11-oxododecanoic acid hydrochloride (Ia) and 9-(dimethylaminomethyl) -10-oxoundecanoic acid (Ib) have been obtained from the mother liquors remaining after filtration of 13-(dimethylamino)-11-oxotridecanoic acid hydrochloride and 12-(dimethylamino)-10-oxododecanoic acid hydrochloride, respectively. 2) 10-Methylene-11-oxododecanoic acid (IVa) and 9-methylene-10-oxoundecanoic acid (IVb) have been synthesized from the Mannich bases Ia and Ib, respectively. 3) Antitumor activities of IVa and IVb have been described.

10-Methylene-11-oxododecanoic acid and 9-Methylene-10-oxoundecanoic acid show promising antitumor activities when synthesized from Mannich bases Ia and Ib.

Bulletin of the Chemical Society of Japan

Studies on Antibiotics and Related Substances. XIII. Syntheses of 10-Methylene-11-oxododecanoic Acid and 9-Methylene-10-oxoundecanoic Acid, Antitumor Substances

Paper

Studies on Antibiotics and Related Substances. XIII. Syntheses of 10-Methylene-11-oxododecanoic Acid and 9-Methylene-10-oxoundecanoic Acid, Antitumor Substances

References

Citations