Studies on antihyperlipidemic agents. III. Synthesis and biological activities of 2-chloro-3-arylpropionic acids containing a quarternary carbon atom.
Published Sep 2, 1980 · Y. Kawamatsu, H. Asakawa, T. Saraie
Arzneimittel-Forschung
UNKNOWN SJR score
3
Citations
0
Influential Citations
Abstract
A series of 2-chloro-3-(4-alkoxyphenyl)propionic acids containing a quarternary carbon atom in the alkoxy moiety was prepared and the hypolipidemic and hypoglycemic activities were evaluated. Of the 18 compounds synthesized, ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate (1) was the best with respect to biological activity and toxicity. Its functional derivatives and optically resolved enantiomers were also prepared. Structure-activity relationships are discussed briefly.
Study Snapshot
Key takeawayEthyl 2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate (1) shows the best hypolipidemic and hypoglycemic activity, with its functional derivatives and optically resolved enantiomers also prepared.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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