Studies on Azolylacetonitriles: The Reactivity of Thiazole-2-yl, Thiadiazol-2-yl Acetonitriles Toward Electrophilic Reagents

doi:10.1080/10426500211731

Paper

Studies on Azolylacetonitriles: The Reactivity of Thiazole-2-yl, Thiadiazol-2-yl Acetonitriles Toward Electrophilic Reagents

Published May 1, 2002 · M. Elnagdi, M. Selim, F. Latif

Phosphorus, Sulfur, and Silicon and the Related Elements

UNKNOWN SJR score

5

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Abstract

5-Acetyl-2-cyanomethyl-4-methylthiazole, 2-aminothiazole, and 5-N-benzoylamino-1,3,4-thiadiazole-2-yl-acetonitrile react with acetone, and malononitrile derivatives in the presence of sulfur to yield the corresponding thiophene derivatives. Also, 4-furylmethylene-2-phenyl-2-oxazolin-5-ones react with thiophenol, and/or thionaphthol to give the thiolester derivatives in one-pot synthesis. The structures of the products were based on IR, 1 H NMR, and elemental analysis.

Study Snapshot

Thiazole-2-yl and thiadiazol-2-yl acetonitriles show reactivity towards electrophilic reagents, yielding thiophene derivatives and thiolester derivatives in one-pot synthesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Studies on Azolylacetonitriles: The Reactivity of Thiazole-2-yl, Thiadiazol-2-yl Acetonitriles Toward Electrophilic Reagents

References

An improved synthesis of pyrazolo[3,4‐b][1,5]benzoxazepine, ‐benzothiazepine and ‐benzodiazepine derivatives via a convenient one‐pot synthesis

This improved one-pot method allows for the preparation of pyrazolo[3,4-b][1,5]benzoxazepine, -benzothiazepine, and -benzodiazepine derivatives with a simple, efficient, and environmentally friendly approach.

A ONE-POT SYNTHESIS OF PYRAZOLO [3,4-b][1,4]OXAZINES

This study presents a new, efficient, and simple one-pot method for the synthesis of pyrazolo[3,4-b][1,4]oxazines using available laboratory materials.

Ring-Opening Ringn-Closure of 4-Phenyl-1,2-Dithiole-3-Thione. Novel Synthesis of Thio-Pyrano[2,3-B]Pyrane Derivatives

This study demonstrates a novel synthetic method for thio-pyrano[2,3-B]pyrane derivatives using ring-opening ring-closure reactions and nucleophilic attack at the dithiole ring.

The Reaction of Arylidenemalonodinitriles with 1-Arylethylideneaminobenzenes. A New Synthesis of 5′-Amino-1,1′:3′, 1″-terphenyl-2′, 6′-dicarbonitriles

The exchange reaction between arylidenemalonodinitriles and 1-arylethylideneaminobenzenes leads to the synthesis of 5′-amino-1,1′:3′,1′′-terphenyl-2′,6′-dicarbonitrile

Studies on alkylheteroaromatic compounds. The reactivity of alkyl polyfunctionally substituted azines towards electrophilic reagents

Alkyl polyfunctionally substituted azines show reactivity towards electrophilic reagents, enabling new synthesis of substituted phthalazines, cinnolines, and quinazolines.

Citations

Synthesis of Pyrazolo[1,5‐a][1,3,5]triazine, Pyrazolo[1,5‐a]pyrimidine, and Imidazo[1,2‐b]pyrazole Derivatives Based on Imidazo[2,1‐b]thiazole Moiety

This study synthesized pyrazolo[1,5-a][1,3,5]triazine, pyrazolo[1,5-a]pyrimidine, and imidazo[1,2b]pyrazole derivatives based on imidazo[2,1-b]thiazo

Synthesis and Reactivity of 3-oxoprop-1-en-1-olate Derivative as a Building Block for the Synthesis of Azole and Azine Derivatives

This study demonstrates the potential of sodium 3-(4-methyl-2-(4-methylphenylsulfonamido)thiazol-5-yl)-3-oxoprop-1-en-1-olate) as a versatile building block for the synthesis of azole and azin

Synthesis and Reactivity of Enaminones: A Facile Synthesis of Thiophene and 1,3,4-Thiadiazole Derivatives Incorporating a Thiazole Moiety

This study demonstrates a facile synthesis of thiophene and 1,3,4-thiadiazole derivatives incorporating a thiazole moiety, offering potential applications in various fields.

Studies with Azinylacetonitriles: 2-Pyridylacetonitrile as a Precursor to Functionally Substituted Pyridines

2-Pyridylacetonitrile can be used as a precursor to functionally substituted pyridines, with potential applications in pharmaceuticals and nutraceuticals.