Studies on uricosuric diuretics. III. Substituted 1,3-dioxolo[4,5-f]-1,2-benzisoxazole-6-carboxylic acids and 1,3-dioxolo[4,5-g]-1,2-benzisoxazole-7-carboxylic acids.

doi:10.1248/CPB.40.109

Paper

Studies on uricosuric diuretics. III. Substituted 1,3-dioxolo[4,5-f]-1,2-benzisoxazole-6-carboxylic acids and 1,3-dioxolo[4,5-g]-1,2-benzisoxazole-7-carboxylic acids.

Published Jan 25, 1992 · H. Satō, T. Dan, E. Onuma

Chemical & pharmaceutical bulletin

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Abstract

A series of substituted 1,3-dioxolo[4,5-f]-1,2-benzisoxazole-6-carboxylic acids 13 and 1,3-dioxolo[4,5-g]-1,2-benzisoxazole-7-carboxylic acids 14 were synthesized and evaluated for diuretic and uricosuric activities in rats. Most of the benzisoxazole derivatives 13 and 14 showed potent diuretic activities. Moderate uricosuric activities were also found in 14a, 14b, and 14f.

Non-RCT

Animal Study

Study Snapshot

Substituted 1,3-dioxolo[4,5-f]-1,2-benzisoxazole-6-carboxylic acids 13 and 14, show potent diuretic activities and moderate uricosuric activities in rats.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Studies on uricosuric diuretics. III. Substituted 1,3-dioxolo[4,5-f]-1,2-benzisoxazole-6-carboxylic acids and 1,3-dioxolo[4,5-g]-1,2-benzisoxazole-7-carboxylic acids.

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References

Citations

Integrating Metal-Catalyzed C-H and C-O Functionalization To Achieve Sterically Controlled Regioselectivity in Arene Acylation.

This study demonstrates steric-controlled regioselective arene acylation with salicylate esters via iridium catalysis, leading to the synthesis of the potent anticancer agent hydroxyphenstatin.

Synthesis and Aminomethylation of 3-Substituted 6-Hydroxy-1,2-Benzisoxazoles

This study successfully synthesized 3-substituted 6-hydroxy-1,2-benzisoxazoles and explored their aminomethylation reactions with various reagents.

Solution-phase synthesis of a diverse library of benzisoxazoles utilizing the [3 + 2] cycloaddition of in situ-generated nitrile oxides and arynes.

This study successfully synthesized a diverse library of benzisoxazoles using the [3 + 2] cycloaddition of nitrile oxides and arynes, resulting in diverse 3,5,6-trisubstituted benzisoxazoles with good to excellent yields

Expeditious synthesis of bioactive allylphenol constituents of the genus Piper through a metal-free photoallylation procedure.

This metal-free photoallylation procedure efficiently synthesizes bioactive allylphenol constituents from Piper plants in medium to high yield, with eugenol, safrole, and asaricin being the most studied compounds.

Synthesis and inhibitory effects on platelet aggregation of 3-(2-thienyl)- and 3-(1-imidazolyl)-1,2-benzisoxazole derivatives

The most active compound (7-methoxy-3-(2-thienyl)-1,2-benzisoxazole 5c) is 20-30-fold more potent than acetylsalicylic acid in inhibiting platelet aggregation.