Molecular orbital studies on nucleoside antibiotics, VII. Conformation of 2′-amino- 2′-deoxyguanosine

doi:10.1007/BF01857616

Paper

Molecular orbital studies on nucleoside antibiotics, VII. Conformation of 2′-amino- 2′-deoxyguanosine

Published Mar 1, 1984 · L. N. Patnaik, A. Saran

Journal of Biological Physics

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Abstract

Conformational properties of the nucleoside antibiotic 2′-amino-2′-deoxyguanosine have been investigated by the PCILO method along with those of its parent nucleoside, guanosine. This antibiotic, formed by replacement of the 2′-hydroxyl group by an amino group in guanosine, shows anti-tumor activity and also inhibits RNA and protein syntheses. Both C(2′)-endo and C(3′)-endo sugar conformations have been considered in the computations. The results indicate striking similarity between the conformations of the antibiotic and the parent nucleoside, particularly in simulated aqueous environment. The biological implication of this result in terms of the antibiotic activity is discussed.

Study Snapshot

The conformational properties of 2′-amino-2′-deoxyguanosine show striking similarity to its parent nucleoside, guanosine, suggesting potential biological implications for its anti-tumor activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Molecular orbital studies on nucleoside antibiotics, VII. Conformation of 2′-amino- 2′-deoxyguanosine

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