The titled compound, 2-amino-3-cyanopyrazine (1), was prepared by reaction of 3-aminopyrazine 1-oxide (7) with trimethylsilyl cyanide. Furthermore, conditions of individual steps in synthetic route to 7 starting from 2-pyrazinecarboxamide were optimized.

This study presents a new and convenient synthesis of 2-amino-3-cyanopyrazine by reacting 3-aminopyrazine 1-oxide with trimethylsilyl cyanide, optimizing the synthetic route to 7.

Paper

Studies on pyrazines. 18. A new and convenient synthesis of 2‐amino‐3‐cyanopyrazine

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