Studies on pyrrolidinones. Synthesis of some N-fatty acylpyroglutamic acids

doi:10.1002/JHET.5570320513

Paper

DOI: 10.1002/JHET.5570320513

Studies on pyrrolidinones. Synthesis of some N-fatty acylpyroglutamic acids

Published Sep 1, 1995 · B. Rigo, Antonios Kolokouris, N. Kolokouris

Journal of Heterocyclic Chemistry

Q3 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Starting from readily available pyroglutamic acid 1, some N-fatty acylpyroglutamic acids were synthesized and characterized by their spectral data. A preliminary pharmacological study showed that N-stearoylpyroglutamic acid 4c displays a CNS stimulating effect on mice.

Study Snapshot

N-stearoylpyroglutamic acid 4c shows a CNS stimulating effect on mice, demonstrating potential as a novel neurotransmitter.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1021/JM00044A010

Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2.

New aminoadamantane derivatives show marked antiviral activity against influenza A H2N2, H3N2, and H1N1, suggesting a potential mechanism of action similar to amantadine and rimantadine.

1994·69citations·N. Kolocouris et al.·Journal of Medicinal Chemistry

Journal of Medicinal Chemistry

DOI: 10.1021/JM00106A025

Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives.

1-acyl-2-pyrrolidinone derivatives show anticonvulsant activity, with 1-decanoyl-2-pyrrolidinone (7) and 1-dodecanoyl-2-pyrrolidinone (8) showing high activity, suggesting their potential as GABA release inhibitors.

1991·41citations·Hitoshi Sasaki et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/0031-6989(87)90040-3

Effect of pyroglutamic acid stereoisomers on ECS and scopolamine-induced memory disruption and brain acetylcholine levels in the rat.

D,L-pyroglutamic acid (D,L-PCA) effectively prevents memory disruption and decreases brain acetylcholine levels in rats, showing cognition-enhancing properties.

1987·24citations·G. Spignoli et al.·Pharmacological research communications

Pharmacological research communications

DOI: 10.1016/0197-0186(86)90013-6

Uptake and metabolism of l-[3H]pyroglutamic acid in neuronal and glial cells in culture

Glial cells play a crucial role in pyroglutamate uptake and metabolism in nervous tissue, suggesting that pyroglutamate may interfere with glutamate neurotransmission in vivo.

1986·10citations·J. Borg et al.·Neurochemistry International

Neurochemistry International

DOI: 10.1016/0014-4886(84)90197-3

Neurotoxic effects of endogenous materials: Quinolinic acid, l-pyroglutamic acid, and thyroid releasing hormone (TRH)

Quinolinic acid has a selective neurotoxic action, while thyroid releasing hormone shows slight neurotoxicity, but not l-pyroglutamic acid.

1984·30citations·E. Mcgeer et al.·Experimental Neurology

Experimental Neurology

DOI: 10.1126/SCIENCE.6836290

Selective modification of glutathione metabolism.

Selective modification of glutathione metabolism, using enzyme inhibitors and compounds that increase synthesis, can enhance chemotherapy and radiation therapy by protecting cells from toxic effects of drugs, foreign compounds, and oxygen.

1983·1264citations·A. Meister·Science

Science

DOI: 10.1073/PNAS.79.20.6246

Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.

L-2-oxothiazolidine-4-carboxylate protects against acetaminophen toxicity in mice by promoting glutathione synthesis, which may be useful in treating other toxicities and diseases.

1982·278citations·J. Williamson et al.·Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

DOI: 10.1016/0378-4274(82)90070-4

Plasma and brain levels of glutamate and pyroglutamate after oral monosodium glutamate to rats.

Oral monosodium glutamate increases plasma pyroglutamate levels in rats, but does not affect brain levels, while pyroglutamate accumulates in the brain in a dose-dependent manner.

1982·34citations·S. Caccia et al.·Toxicology letters

Toxicology letters

DOI: 10.1016/0304-3940(77)90175-6

In vivo incorporation of exogenous stearic acid in synaptosomes: High occurrence of non-esterified fatty acids

Stearic acid is incorporated into synaptosomal lipids in the brain, with phospholipids acting as potent acceptors, and high radioactivity found in non-esterified fatty acids.

1977·7citations·J. Bourre et al.·Neuroscience Letters

Neuroscience Letters

Citations

DOI: 10.1016/j.jcou.2021.101782

Carbon dioxide transformation as a green alternative to phosgene and chloroformates: N-carboxyalkylation of lactams and analogues

This study developed a green, safe, and efficient method for N-carboxyalkylation of lactams, offering a green alternative to phosgene and chloroformates for carbon capture and use solutions.

2021·1citation·Germain Homerin et al.·Journal of CO2 Utilization

Journal of CO2 Utilization

DOI: 10.1134/S1070363219120363

Application of the Cleavable Isocyanide in Efficient Approach to Pyroglutamic Acid Analogues with Potential Biological Activity

The developed methods efficiently synthesize pyroglutamic acid analogues 28, 29, and 34, with potential biological activity, using 1-(2,2-dimethoxyethyl)-2-isocyanobenzene as a cleavable isocyanide and strong nucleophile.

2019·6citations·A. Jassem et al.·Russian Journal of General Chemistry

Russian Journal of General Chemistry