Study on compounds with potential antitumor activity. III. Hydrazone derivatives of 5-substituted 2-chloro-3-formyl-6-methylindole.

doi:10.1002/CHIN.197924211

Paper

Study on compounds with potential antitumor activity. III. Hydrazone derivatives of 5-substituted 2-chloro-3-formyl-6-methylindole.

Published Feb 1, 1979 · A. Andreani, M. Rambaldi, D. Bonazzi

Il Farmaco; edizione scientifica

UNKNOWN SJR score

5

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Abstract

The synthesis of 5-methoxy- (IX) and 5-hydroxy- (X) 2-chloro-3-formyl-6-methylindole is reported: three hydrazonic derivatives were prepared from each compound. Preliminary results on the activity of the six derivatives against P388 leukemia in mice are reported.

Study Snapshot

5-methoxy- (IX) and 5-hydroxy- (X) 2-chloro-3-formyl-6-methylindole derivatives show potential antitumor activity against P388 leukemia in mice.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Study on compounds with potential antitumor activity. III. Hydrazone derivatives of 5-substituted 2-chloro-3-formyl-6-methylindole.

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References

Citations

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Synthesis, Evaluation of Antioxidant Activity and Crystal Structure of 2,4-Dimethylbenzoylhydrazones

2,4-Dimethylbenzoylhydrazones show promising antioxidant activity, with compounds 1, 2, 3, 7, and 6 showing better activity than n-propyl gallate.

Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

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Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.

Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones show antitumor activity in MCF-7 breast cancer cells, inhibiting growth and promoting apoptosis through increased p53 levels and cell cycle