Study on the Inhibition Mechanism of 4-(4-Hydroxyphenethyl) Benzene-1,2-Diol on Urease

Paper

Study on the Inhibition Mechanism of 4-(4-Hydroxyphenethyl) Benzene-1,2-Diol on Urease

Published 2012 · Xiao Zhu-ping

Journal of Jishou University

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Abstract

4-(4-Hydroxyphenethyl)benzene-1,2-diol is a new inhibitor against Helicobacter Pylori urease.The inhibition mechanism was herein investigated through enzyme kinetics methods,and the results revealed that 4-(4-hydroxyphenethyl)benzene-1,2-diol was competitive inhibitor of urease with a Ki value of 1.48 μmol/L.The chemical stabilitiy and the competitive mechanism of 4-(4-hydroxyphenethyl)-benzene-1,2-diol strongly suggested that it could be used as a lead compound for rational drug design to find active compound and as a potential urease inhibitor for treatment of gastritis and peptic ulcer.

In Vitro Study

Study Snapshot

4-(4-hydroxyphenethyl)benzene-1,2-diol shows potential as a urease inhibitor for treating gastritis and peptic ulcer due to its chemical stability and competitive mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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