Paper

Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase.

Published Jan 15, 2011 · H. Yanagita, Emiko Urano, Kisho Matsumoto

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Derivatives of 5-nitro-furan-2-carboxylic acid show high inhibitory activities against HIV-1 reverse transcriptase's RNase H function, offering potential for new antiviral drugs against drug-resistant viruses.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase.

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