Paper
Study of leaving groups for the preparation of [ω-18F]fluorofatty acids via nucleophilic fluorination and its application to the synthesis of 17-[18F]fluoro-3-methylheptadecanoic acid
Published 1991 · Toshihiro Takahashi, T. Ido, R. Iwata
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes
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Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Tosylate and bromide are the most reactive leaving groups for introducing [18F]fluorine into fatty acids via nucleophilic fluorination, leading to the synthesis of 17-[18F]fluoro-3-methylheptadecanoic acid for medical studies.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Citations
Equilibrium spreading pressure and Langmuir–Blodgett film formation of omega-substituted palmitic acids
Omega-substituted palmitic acids with terminal heteroatom substituents show reduced stability and lower equilibrium spreading pressures compared to compounds with CH 3 and F terminated compounds.
2014·7citations·A. Snow et al.·Thin Solid Films
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Syntheses and Uses of Isotopically Labelled Organic Halides
Isotopically labeled organic halides are useful for synthesis and studies of various compounds, aiding in understanding chemical reactions and their effects.
2009·0citations·M. Zieliński et al.·Patai's Chemistry of Functional Groups
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Radiosynthesis of novel 18F-labelled derivatives of indiplon as potential GABAA receptor imaging tracers for PET
Novel 18F-labelled indiplon derivatives show potential as GABAA receptor imaging tracers for PET, with good radiochemical yield, purity, and specific activity.
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Improved synthesis of pure [18F]fluoro-compounds for PET studies from bromo-compounds.
This study proposes a two-step process for preparing pure [18F]fluoro-compounds for PET studies, resulting in 65-85% yield for most commercial bromo-compounds and 84-90% yield for cold run conversion of bromo-compounds.
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Biological evaluation of 5-methyl-branched-chain omega-[18F]fluorofatty acid: a potential myocardial imaging tracer for positron emission tomography.
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Synthesis of C-11 and F-18 labelled compounds for biomedical applications: Current status and challenges for the future
C-11 and F-18 labelled compounds for biomedical applications show promise for neurology, cardiology, oncology, and human biochemistry and physiology, but current production and automated chemistry challenges need to be addressed for future applications.
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8-[18F]fluorooctanoic acid and its beta-substituted derivatives as potential agents for cerebral fatty acid studies: synthesis and biodistribution.
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Nuclear medicine and biology
Synthesis of 17-[18F]fluoro-5-methylheptadecanoic acid
17-[18F]fluoro-5-methylheptadecanoic acid can be synthesized in 85-100 minutes, with radiochemical purity of >97% and 10-17% isolated yields after emulsification.
1992·2citations·Toshihiro Takahashi et al.·International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes
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