2-(3-Benzoylphenyl)propionitrile which was an important intermediate of ketoprofen was synthesized from 3-benzoylbenzeacetonitrile via monomethylation in the presence of dimethyl carbonate,Pure compound was obtained and the content of crystal was about 99.7%. The influence of catalysts,reaction temperature and reaction time on reactions were discussed.

Monomethylation of 3-benzoylbenzeacetonitrile in the presence of dimethyl carbonate effectively synthesizes 2-(3-Benzoylphenyl)propionitrile, an intermediate in ketoprofen production.

Paper

Study on Monomethylation of 3-Benzoylbenzeacetonitrile

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