Synthetic study of peptide aldehyde via acetal/thioacetal transformation: application for Lys/Ser-containing peptides

doi:10.1016/J.TET.2015.03.080

Paper

DOI: 10.1016/J.TET.2015.03.080

Synthetic study of peptide aldehyde via acetal/thioacetal transformation: application for Lys/Ser-containing peptides

Published May 27, 2015 · H. Konno, Y. Sema, Yoshinori Tokairin

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Abstract

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Study Snapshot

This study successfully synthesized Lys and Ser-containing peptide aldehydes using the efficient transformation of acetal/thioacetal structures and N-bromo succinimide treatment, suggesting this methodology has good potential for practical applications.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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DOI: 10.1002/ejoc.201901256

Solid Phase‐Supported Synthesis of Muraymycin Analogues

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Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor

SK80, a phenylisoserine derivative, shows potential as a SARS-CoV 3CL protease inhibitor with an IC50 value of 43 M against the R188I mutant protease.

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