A novel three-component, one-pot reaction between primary (S)-amino acid amides, aldehydes and isocyanides in the presence of acetic acid yielding substituted 2-(cyanomethylamino)-acetamides 4 in good yields, is described. First efforts to investigate the mechanism of this reaction were undertaken.

This novel three-component reaction efficiently produces substituted 2-(cyanomethylamino)-acetamides in good yields from primary (S)-amino acid amides, aldehydes, and isocyanides in the presence of acetic acid.

Paper

Substituted 2-(cyanomethyl-amino)-acetamides by a novel three-component reaction

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