The synthesis and antiinflammatory activity of a series of substituted (2-phenoxyphenyl)acetic acids are described. Initial screening in the adjuvant arthritis test showed that halogen substitution in the phenoxy ring enhanced activity considerably. Ulcerogenic potential, as measured by the minimum ulcerogenic dose (MUD), was low in almost all the acids tested. [2-(2,4-Dichlorophenoxy)phenyl]acetic acid possessed the most favorable combination of potency with low toxicity, including ulcerogenicity, and this compound is now in therapeutic use.

Substituted (2-phenoxyphenyl)acetic acids show antiinflammatory activity and low toxicity, with [2-(2,4-Dichlorophenoxy)phenyl]acetic acid being the most effective and in therapeutic use.

Paper

Substituted (2-phenoxyphenyl)acetic acids with antiinflammatory activity. 1.

References

Citations