The substrate analog, bromopyruvate, as both a substrate and alkylating agent for 2-keto-3-deoxy-6-phosphogluconic aldolase. Kinetic and stereochemical studies.

doi:10.1016/s0021-9258(19)45058-8

Paper

The substrate analog, bromopyruvate, as both a substrate and alkylating agent for 2-keto-3-deoxy-6-phosphogluconic aldolase. Kinetic and stereochemical studies.

Published Jul 10, 1972 · H. Meloche, M. Luczak, J. M. Wurster

The Journal of biological chemistry

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25

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Abstract

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In Vitro Study

Study Snapshot

The substrate analog bromopyruvate acts as both a substrate and alkylating agent for 2-keto-3-deoxy-6-phosphogluconic aldolase, with a constant ratio of detritiation to enzyme inactivation at about 50:1.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

The substrate analog, bromopyruvate, as both a substrate and alkylating agent for 2-keto-3-deoxy-6-phosphogluconic aldolase. Kinetic and stereochemical studies.

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